EP News: Basic and Translational

While SCN5A is the cardiac sodium channel gene, the role of SCN10A in cardiac conduction is not well characterized. Macri et  al (Circ Genom Precis Med 2018;11:e001663, PMID 29752399) sequenced SCN10A locus in 3699 European-ancestry individuals to identify variants associated with cardiac conduction and replicated findings in 21,000 individuals of European ancestry. They examined human atrial tissues and the biophysics o f ion channel function and identified 2 intronic single nucleotide polymorphisms in high linkage disequilibrium with each other to be the strongest signals for PR and QRS intervals.

Source: Heart Rhythm - July 26, 2018 Category: Cardiology Authors: Penelope A. Boyden Tags: EP News Source Type: research