Combined external beam radiotherapy with carbon ions and tumor targeting endoradiotherapy.

We report on combination effects of these two promising strategies. Tumor targeting 131I-labelled anti-EGFR-antibody (Cetuximab) was used in the prototypic EGFR-expressing A431 human squamous cell carcinoma xenograft model. A 131I-labelled melanin-binding benzamide derivative was utilized targeting B16F10 melanoma in an orthotopic syngeneic C57bl6 model. Fractionated EBRT was performed using carbon ions in direct comparison with conventional photon irradiation. Tumor uptake of 131I-Cetuximab and 131I-Benzamide was enhanced by fractionated EBRT as determined by biodistribution studies. This effect was independent of radiation quality and significant for the small molecule 131I-Benzamide, i.e.,>30% more uptake in irradiated vs. non-irradiated melanoma was found (p
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research

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ConclusionsAdherence to quality of cancer care criteria at the different hospitals evaluated varied. Our findings could be useful for identifying areas for improvement at different hospitals. Future studies should focus on measuring both process and outcome indicators.ResumenIntroducción y objetivosRecientemente se han consensuado unos indicadores de calidad de la atención del cáncer de piel no melanoma y melanoma promovidos por la Fundación Piel Sana AEDV. El objetivo de este estudio es conocer la adherencia a estos criterios de calidad asistencial.Material y métodosEn noviembre de 2016 ...
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
Merkel cell carcinoma (MCC) is an extremely aggressive skin cancer that must be distinguished from other basaloid cutaneous neoplasms that have different treatments and prognoses. This is sometimes challenging in small shave specimens, crushed samples, lymph nodes, and core needle biopsies. Insulinoma-associated protein 1 (INSM1) immunohistochemistry is a sensitive nuclear marker of neuroendocrine differentiation. INSM1 staining was performed on 56 MCC (47 primary tumors, 9 nodal metastases), 50 skin control cases that included basal cell carcinomas, basaloid squamous cell carcinomas, Bowen disease, sebaceous neoplasms, me...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
Publication date: Available online 27 September 2018Source: Seminars in Cancer BiologyAuthor(s): Liang Dong, Xiaoming Lyu, Oluwasijibomi Damola Faleti, Ming-Liang HeAbstractThe T-box factors belong to an ancient protein family, which comprises a cluster of evolutionarily-conserved transcription factors that regulate gene expression and that are crucial to embryonic development. T-box transcription factor 3 (Tbx3) is a member of this family, is expressed in some tissues, and is a key regulator in many critical organs, including the heart, mammary gland, and limbs. Overexpression of Tbx3 is associated with a number of cancer...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Dermatological follow-up is important in OTRs, due to the higher risk of tumors and mainly NMSC. Clinical and environmental factors, including cigarette smoking, are useful in characterizing OTR with higher risk of NMSC. PMID: 30251802 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
CONCLUSIONS: This study demonstrated the increased risk of skin cancer in transplant patients during the first 7 years of follow-up and made the dermatologists aware about the need of a regular cutaneous follow up for this subset of patients. PMID: 30229636 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
Opinion statementDermatoscopy (dermoscopy) improves the diagnosis of benign and malignant cutaneous neoplasms in comparison with examination with the unaided eye and should be used routinely for all pigmented and non-pigmented cutaneous neoplasms. It is especially useful for the early stage of melanoma when melanoma-specific criteria are invisible to the unaided eye. Preselection by the unaided eye is therefore not recommended. The increased availability of polarized dermatoscopes, and the extended use of dermatoscopy in non-pigmented lesions led to the discovery of new criteria, and we recommend that lesions should be exa...
Source: Current Treatment Options in Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 13 September 2018Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): A.J. Dalal, J. Ingham, B. Collard, G. MerrickAbstractWe provide a non-melanoma skin cancer (NMSC) service for skin cancers of the head and neck in the south-west of England. We hypothesised that certain anatomical sites such as the nose and eyelid would have a higher incidence of close or involved margins than others, and that the choice of repair might influence the excised margins. We therefore retrospectively analysed the data of 500 consecutive NMSC that were operated on in the oral and maxillofacial ...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Conclusion: Because of the significant correlation of MAGEA4 and indices of poor prognosis, the role of this CTA may be confirmed in ESCC aggressiveness and metastasis. Therefore, MAGEA4 may be a promising therapeutic candidate for suppressing ESCC aggressiveness.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
Cutaneous Squamous cell carcinoma (cSCC) is after basal cell carcinoma the second most common non-melanoma skin cancer and accounts for 20% of all cutaneous malignancies [1]. Particularly effected are organ transplant recipients (OTRs) with a 65 to 250 higher risk than the general population due to their immunosuppression as major risk factor [2]. Moreover, cSCC in OTRs are often quite aggressive with high recurrence rates, metastasis and death [3]. The most widely used agents to prevent graft rejection in solid OTRs are calcineurin-inhibitors in combination with mycophenolate mofetil (MMF) and corticosteroids as the stand...
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
In conclusion, dermoscopy is valuable for the diagnosis of CNH as a first screening tool because of a consistent global dermoscopic configuration (daisy pattern), consisting of radially arranged white thick lines surroun ding a central rounded yellow/brown clod.
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
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