Recent extensions to native chemical ligation for the chemical synthesis of peptides and proteins.

Recent extensions to native chemical ligation for the chemical synthesis of peptides and proteins.
Curr Opin Chem Biol. 2014 Oct 3;22C:70-78
Authors: Malins LR, Payne RJ
Abstract
Native chemical ligation continues to play a pivotal role in the synthesis of increasingly complex peptide and protein targets twenty years after its initial report. This opinion article will highlight a number of recent, powerful extensions of the technology that have expanded the scope of the reaction, accelerated ligation rates, enabled chemoselective post-ligation modifications, and streamlined the ligation of multiple peptide fragments. These advances have facilitated the synthesis of a number of impressive protein targets to date and hold great promise for the continued application of native chemical ligation for the detailed study of protein structure and function.
PMID: 25285753 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - October 3, 2014 Category: Biochemistry Authors: Malins LR, Payne RJ Tags: Curr Opin Chem Biol Source Type: research