Melatonin receptors limit dopamine reuptake by regulating dopamine transporter cell-surface exposure.

In conclusion, we reveal one of the first molecular complexes between G protein-coupled receptors (MT1 and MT2) and transporters (DAT) in which melatonin receptors regulate the availability of DAT at the plasma membrane, thus limiting the striatal DA re-uptake capacity in mice. PMID: 30043140 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30043140?dopt=Abstract

Source: Cellular and Molecular Life Sciences : CMLS - July 24, 2018 Category: Cytology Authors: Benleulmi-Chaachoua A, Hegron A, Le Boulch M, Karamitri A, Wierzbicka M, Wong V, Stagljar I, Delagrange P, Ahmad R, Jockers R Tags: Cell Mol Life Sci Source Type: research