Blocking cyclin-dependent kinase 4/6 during single dose vs. fractionated radiation therapy leads to opposite effects on acute gastrointestinal toxicity in mice

Pharmacological inhibition of CDK4/6 using palbociclib before a single dose of radiation ameliorates the GI-ARS, but it exacerbates the GI-ARS when given before and during fractionated radiation.

Source: International Journal of Radiation Oncology * Biology * Physics - July 26, 2018 Category: Radiology Authors: Chang-Lung Lee, Patrick Oh, Eric Xu, Yan Ma, Yongbaek Kim, Andrea R. Daniel, David G. Kirsch Source Type: research