Megaloblastic Anemia Progressing to Severe Thrombotic Microangiopathy in Patients with Disordered Vitamin B12 Metabolism: Case Reports and Literature Review

We describe 2 children with cobalamin G disease, a disorder of vitamin B12 metabolism with normal serum B12 levels. They presented with megaloblastic anemia progressing rapidly to severe thrombotic microangiopathy. In infants presenting with acute thrombotic microangiopathy, cobalamin disorders should be considered early as diagnosis and targeted treatment can be lifesaving.

Source: The Journal of Pediatrics - July 26, 2018 Category: Pediatrics Authors: Dolores Mullikin, Nishitha Pillai, Rossana Sanchez, Anne H. O'Donnell- Luria, Amy Kritzer, Leyat Tal, Mohammed Almannai, Gerard T. Berry, Michael J. Gambello, Hong Li, Brett Graham, Lakshmi Srivaths, Vernon Reid Sutton, Amanda Grimes Tags: Clinical and laboratory observations Source Type: research