USP10 suppresses tumor progression by inhibiting mTOR activation in hepatocellular carcinoma

Dysregulation of deubiquitination pathway is associated with poor prognosis in cancers such as hepatocellular carcinoma (HCC). The mammalian target of rapamycin, mTOR, has become an attractive cancer therapeutic target in HCC. However, whether and how aberrant expression of deubiquitination pathway regulates mTOR pathway has remained elusive. Here we report that ubiquitin-specific protease 10 (USP10) functions as a tumor suppressor which inhibits mTOR pathway by stabilizing PTEN and AMPK α in HCC cells.

Source: Cancer Letters - July 26, 2018 Category: Cancer & Oncology Authors: Chang Lu, Zhen Ning, Aman Wang, Di Chen, Xiaolong Liu, Tian Xia, Dinesh Singh Tekcham, Wen Wang, Tongming Li, Xiumei Liu, Jing Liu, Huan Qi, Haifeng Luo, Jian Du, Chi Ma, Qiu Yan, Jiwei Liu, Guowang Xu, Hai-long Piao, Guang Tan Tags: Original Articles Source Type: research