The co-identification of mcr-4.6 and blaNDM-1 in a clinical Enterobacter cloacae isolate from China.

The co-identification of mcr-4.6 and blaNDM-1 in a clinical Enterobacter cloacae isolate from China. Antimicrob Agents Chemother. 2018 Jul 23;: Authors: Chavda B, Lv J, Hou M, Chavda KD, Kreiswirth BN, Feng Y, Chen L, Yu F Abstract Here we describe the first report of a clinical colistin-resistant ST84 Enterobacter cloacae isolate co-harboring mcr-4.6 (previously named mcr-4.2) and blaNDM-1 from a patient in China. The blaNDM-1-harboring IncX3 plasmid and the novel mcr-4.6-harboring ColE plasmid were completely sequenced. Although this isolate showed high level resistance to colistin, mcr-4.6 plasmid transformation, gene subcloning, susceptibility testing and lipid A matrix-assisted laser desorption ionization mass spectrometry analysis indicate that mcr-4.6 itself doesn't confer resistance to colistin. PMID: 30038043 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research