Three new C -glycosyflavones with acetyl substitutions from Swertia mileensis

AbstractThree new acetylatedC-glycosylflavones, 3 ″,6″-di-O-acetylswertiajaponin (1), 4 ″,6″-di-O-acetylswertiajaponin (2), and 6 ″-O-acetylswertiajaponin (3), together with six known compounds were isolated from the whole herb ofSwertia mileensis. Their structures were elucidated on extensive NMR experiments and mass spectrometry studies.1H and13C NMR data exhibited doublet signals at room temperature. Variable temperature1H NMR experiments were carried out to investigate the presence of rotational isomerism ofC-glycosylflavones. All compounds showed potential antioxidant activities against apoptosis of H2O2-induced human embryo liver L02 cells.

http://link.springer.com/10.1007/s11418-018-1225-7

Source: Journal of Natural Medicines - July 26, 2018 Category: Drugs & Pharmacology Source Type: research