G-1 exhibit antidepressant effect, increase of hippocampal ERs expression and improve hippocampal redox status in aged female rats.

G-1 exhibit antidepressant effect, increase of hippocampal ERs expression and improve hippocampal redox status in aged female rats. Behav Brain Res. 2018 Jul 21;: Authors: Wang J, Yu R, Han QQ, Huang HJ, Wang YL, Li HY, Wang HM, Chen XR, Ma SL, Yu J Abstract Postmenopausal depression has been shown to be related to the reduction of ovarian hormones produced as a woman transitions from a menopausal to a post-menopausal stage. What remains to be known is which type of estrogen receptor plays a key role in estrogen neuroprotection, a process that may be mediated by potentiating brain mitochondrial function and inhibiting mitochondria-associated apoptosis. In order to better imitate the condition of postmenopause, we conducted our research on aged female rats. Plasma estrogen levels declined significantly in ovariectomized rats and 16-month-old female rats, while anxiety and depression-like behavior increase. Moreover, ERα, ERβ, GPER, Bcl2 and UCP2 expression decreased significantly in hippocampus in female rats following ovariectomy. In our study, the anxiety and depression-like behavior in aged female rats were significantly relieved after the treatment of G-1, the GPER agonist. Furthermore, G-1 could reverse the reduction of ERα, ERβ, GPER, Bcl2 and UCP2 expression within the hippocampus. Mitochondrial JC-1 staining indicated that mitochondrial membrane potential increased after G-1 treatment. In addition, total antioxidant capacity ...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

Related Links:

I am an experienced OB/GYN, well-versed in obstetrics, infertility, gynecology, surgery and — yes — menopause, or so I thought. So why was I so blindsided by my own menopause transition? I thought I was going through burnout, with anxiety, anger, mood swings, irritability, and depression. I was at a point in my career as […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions OB/GYN Source Type: blogs
WEDNESDAY, Sept. 18, 2019 -- Hysterectomy, even with ovarian conservation, is associated with an increased long-term risk for de novo depression, according to a study published online Aug. 30 in Menopause. Shannon K. Laughlin-Tommaso, M.D., from the...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
By 2025, the number of postmenopausal women is expected to approach 1.1 billion worldwide [1]. A majority of women will develop symptoms during the menopausal transition, including but not limited to vasomotor symptoms (VMS), sleep disturbances, mood symptoms, and vaginal dryness [2]. It is important to understand the factors that may influence these symptoms given the rising number of symptomatic women, as well as the significant negative effect these symptoms may have on quality of life [3]. Relationship satisfaction is known to affect health outcomes positively, many times through dyadic coping strategies that may mitig...
Source: Maturitas - Category: Primary Care Authors: Source Type: research
Alternative and Complementary Therapies, Ahead of Print.
Source: Alternative and Complementary Therapies - Category: Complementary Medicine Authors: Source Type: research
Abstract Sutaehwan (STH) has been used in Korean medicine for the treatment of abortus habitualis such as fetal restlessness in the uterus. Previously, we reported that a modified formulation of STH, Sutaehwan-Gami, has phytoestrogen-like properties in an ovariectomized menopausal rat model. However, the therapeutic effects of STH and the precise mechanisms by which STH affects various menopausal symptoms remain poorly understood. The current study was designed to explore the effects of a modified form of STH on menopausal anxiety, depression and heart hypertrophy and its mechanisms in 4-vinylcyclohexene diepoxide...
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research
CONCLUSIONS: Mindfulness meditation training can effectively alleviate the symptoms of anxiety and depression and improve the quality of sleep in perimenopausal women, and the frequency of the exercise is positively correlated with the improvements. Mindfulness meditation training can be an effective intervention for improving the mental health of perimenopausal women. PMID: 31511223 [PubMed - in process]
Source: Journal of Southern Medical University - Category: Universities & Medical Training Authors: Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Objective: To evaluate the effectiveness of cognitive behavioral therapy for menopausal symptoms (CBT-Meno) compared with a waitlist condition (no active intervention). A randomized controlled trial was conducted with 71 perimenopausal or postmenopausal women who were seeking treatment for menopausal symptoms. Methods: Blind assessments were conducted at baseline, 12 weeks postbaseline, and 3 months post-treatment. An intention-to-treat analysis was conducted. CBT-Meno sessions included psychoeducation, and cognitive and behavioral strategies for vasomotor and depressive symptoms, anxiety, sleep difficulties, and sexu...
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
Conclusions: Weak upper and lower body physical performances were associated with depressive and anxiety symptoms in midlife Singaporean women. Future trials are required to determine whether strengthening exercises that improve physical performance could help reduce depressive and anxiety symptoms in midlife women. Video Summary: Supplemental Digital Content 1, http://links.lww.com/MENO/A419.
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
A 'menopause policy' should be standard in the workplace as women battle anxiety, depression, hot flushes and muddled thinking. Women across the country have lost jobs due to symptoms.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conclusions: The MRS and MENQOL display moderate accuracy in discriminating menopausal women with symptoms of anxiety and depression. The intensity of the symptoms appears to be related to the probability of detecting a probable or definitive disorder.
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
More News: Antidoxidants | Anxiety | Brain | Depression | Hormones | Men | Menopause | Mitochondria | Neurology | Ovaries | Study