Which indicators of early cancer diagnosis from population-based data sources are associated with short-term mortality and survival?

Publication date: Available online 25 July 2018Source: Cancer EpidemiologyAuthor(s): Patrick Muller, Sarah Walters, Michel P. Coleman, Laura WoodsAbstractBackgroundA key component of recent English cancer policy is the monitoring of trends in early diagnosis of cancer. Early diagnosis can be defined by the disease stage at diagnosis or by other indicators derived from electronic health records. We evaluate the association between different early diagnosis indicators and survival, and discuss the implementation of the indicators in surveillance of early diagnosis.MethodsWe searched the PubMed database and grey literature to identify early diagnosis indicators and evaluate their association with survival. We analysed cancer registrations for 355,502 cancer patients diagnosed in England during the period 2009–2013, and quantified the association between each early diagnosis indicator and 30-day mortality and five-year net survival.ResultsEach incremental difference in stage (I–IV) predicts lower 5-year survival, so prognostic information is lost in comparisons which use binary stage indicators. Patients without a recorded stage have high risk of death shortly following diagnosis and lower 5-year survival. Emergency presentation is independently associated with lower five-year survival. Shorter intervals between first symptoms and diagnosis are not consistently associated with improved survival, potentially due to confounding from tumour characteristics.InterpretationContrary...
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research