Recurring acute urticaria and abdominal pain: Consider a diagnosis of alpha-galactose anaphylaxis.

DISCUSSION: In the event of acute urticaria associated with systemic symptoms, in particular gastrointestinal signs, allergy to α-galactose should be considered. PMID: 30037744 [PubMed - as supplied by publisher]
Source: Annales de Dermatologie et de Cenereologie - Category: Dermatology Authors: Tags: Ann Dermatol Venereol Source Type: research

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Allergy to galactose-alpha-1,3-galactose (alpha-gal) presents as an IgE-mediated, yet delayed-onset hypersensitivity reaction to non-primate mammalian meat.1 Alpha-gal sensitization develops after tick bite exposure.1-3 The lone-star tick (Amblyomma americanum) represents the North American vector, spanning a relatively vast southeast, mid-west, and northeast geographic distribution.4 Allergic manifestations include urticaria/angioedema, abdominal pain/diarrhea, or anaphylaxis, occurring approximately 3-6 hours after ingestion.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
We present the first case of a delayed, protracted allergic reaction to oral viscous lidocaine with positive intradermal testing.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
The basis of venom immunotherapy (VIT) can be defined as protection against IgE-mediated immunologic mechanisms such as anaphylaxis.1,2 Most insect stings produce local reactions of swelling, pain, erythema and pruritus, typically peaking by 24-48 hours and resolving within 3-10 days.5 Unfortunately, some patients experience systemic reactions ranging from cutaneous reactions only (characterized by urticaria and/or angioedema, excluding throat, larynx and tongue) to life-threatening systemic anaphylactic reactions (SAR).
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
CONCLUSIONS: Incidence of eperisone-induced anaphylaxis calculated from the KIDS-KAERS database was 0.001%. Eperisone can cause hypersensitive reactions, including anaphylaxis, possibly by inducing non-immunoglobulin E-mediated immediate hypersensitivity. PMID: 30661315 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
These days, it can seem like just about everybody has a food allergy. But according to a new study, about 11% of American adults actually do. Yet 19% of adults believe they have a food allergy, even though some don’t have the diagnosis or symptoms to back it up, according to findings published in JAMA Network Open. This discrepancy suggests that quite a few adults are conflating allergies with less-severe food intolerances, which typically come with minimal digestion-related symptoms, the researchers write. If someone is truly allergic to a food, eating it can trigger a potentially life-threatening immune response. (...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Research Source Type: news
ConclusionThe diagnostic work-up begins with a  detailed patient’s history. Skin tests are only useful in SNIDR and SNIUAA, while in vitro tests are helpful merely in exceptional cases. In general, the diagnosis can only be confirmed by provocation testing, when required. Although cross-reactivity is usually present, provocation testing is of ten able to find an alternative, tolerable analgesic. Individual patient management usually enables a solution to be found for most patients.
Source: Allergo Journal International - Category: Allergy & Immunology Source Type: research
Answer: Probable anisakid (Anisakissp.,Pseudoterranovasp., orContracaeceumsp.)There was a lot of great discussion on this case! While we can't definitively rule out a migratory immatureAscaris lumbricoides(crawling up from its usual intestinal location),the size of the worm, morphology, and patient history are most consistent with this being an anisakid larva. Anisakiasis occurs in humans following consumption of undercooked fish or seafood containing coiled anisakid larvae. The larvae cannot mature in humans but still have the potential to cause significant problems for their unintended human host. In the'best case scenar...
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
Follow me on Twitter @drClaire Stomachaches are incredibly common in children. Most of the time they are nothing serious at all. Most are just from a mild stomach bug, or some constipation, or hunger — or are a child’s way of getting out of something they don’t want to do. But a stomachache can sometimes be a sign of a more serious problem. A stomachache worries doctors when… 1.  The pain is severe. By severe, I mean that the child cannot be distracted from it, and is crying or otherwise showing that they are extremely uncomfortable. Any severe pain warrants a trip to the doctor, whether it&rs...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Children's Health Digestive Disorders Parenting Source Type: blogs
People who don’t have a diagnosis for celiac disease or a wheat allergy may face a lot of scorn and derision for claiming to be sensitive to wheat products, skipping pasta and bread.  But a new study by scientists at Columbia University may explain why certain grain products can cause intestinal discomfort in some people, even if they don’t have a widely-recognized medical condition. It may also present doctors with a new way to test for this non-celiac wheat sensitivity, which for now has no diagnostic measure and must be assessed clinically, according to a person’s symptoms. Not everyone who feels ...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Abstract The concept of allergic reaction currently includes all those where an immunological reaction depends on a reaction mediated by IgE, as well as those that involve other immune mechanisms, such as T-cell regulators. There are many different clinical situations, like the classic immediate reactions (IgE mediated) such as urticaria, angioedema, immediate vomiting, abdominal pain, both upper respiratory (aphonia or rhinitis) and lower (wheezing or dyspnoea) symptom, and cardiovascular symptoms. The reactions that involve more than one organ, such as anaphylaxis, which could be an anaphylactic shock if there i...
Source: Anales de Pediatria - Category: Pediatrics Authors: Tags: An Pediatr (Barc) Source Type: research
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