Inhibition of CD300f Function on Dendritic Cells Promotes Tumor Destruction

Cancer immunotherapy aims to enhance the ability of a patient ’s own immune response to destroy tumors. The magnitude of the immune response is determined by the balance between immune activating signals and negative inhibitory signals. Checkpoint receptors are negative regulators that normally deliver inhibitory signals which limit immune activation. Bloc kade of immune checkpoints represents an effective strategy to enhance the immune response against cancer cells.NIAID researchers have discovered that blocking CD300f function in dendritic cells markedly enhances their ability to phagocytose and process apoptotic tumor cells, leading to substantial inhibition of tumor growth. In this light, CD300f may be viewed as a dendritic cell checkpoint receptor analogous to T cell checkpoint receptors like PD-1 and CTLA-4. As a result, inhibiting CD300f function on dendritic cells could be a promising anti-cancer therapy, especially in the settings where blocking of T cell checkpoint receptors has been ineffective.This technology is available for licensing for commercial development in accordance with 35 U.S.C. § 209 and 37 CFR Part 404, as well as for further development andIC: NIAIDNIH Ref. No.: E-257-2016-0Advantages: A novel approachApplications: Cancer immunotherapyProvider Technology ID: 3308Updated On: Jul 23, 2018Date Published: Monday, July 23, 2018Provider Classifications: Patent Application: 62/408,596PCT/US2017/056192Publicat...

Source: NIH OTT Licensing Opportunities - July 23, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research