Mixed Results with MRI for Liver Triglycerides in NAFLD (CME/CE)
(MedPage Today) -- Proton density fat fraction MRI correlated with steatosis grade; suboptimal for advanced fibrosis
This study analyzed 15 randomized, controlled trials involving 782 patients with NAFLD. Probiotics and synbiotics supplementation could significantly improve liver steatosis, alanine aminotransferase, aspartate aminotransferase, triglyceride, total cholesterol, high-density lipoprotein, low-density lipoprotein, homeostasis model assessment-insulin resistance, liver stiffness and tumor necrosis factor-alpha (allP
Authors: Li AA, Ahmed A, Kim D Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and encompasses a spectrum of pathology from simple steatosis to inflammation and significant fibrosis that leads to cirrhosis. NAFLD and its comorbid conditions extend well beyond the liver. It is a multisystemic clinical disease entity with extrahepatic manifestations such as cardiovascular disease, type 2 diabetes, chronic kidney disease, hypothyroidism, polycystic ovarian syndrome, and psoriasis. Indeed, the most common causes of mortality in subjects with NAFLD are cardiovascular disease, f...
ConclusionIn individuals with diabetes and NAFLD, PNPLA3 gene rs738409 C>G polymorphism is a risk marker for significant liver fibrosis and cardiovascular disease and may be associated with better glycemic control.
Conditions: Nonalcoholic Fatty Liver; Metabolic Syndrome Intervention: Sponsor: Hippocration General Hospital Completed
CONCLUSIONS: The immunohistochemical expression of TGF-β1 may be complementary to routine methods of liver fibrosis evaluation. PMID: 31187872 [PubMed - as supplied by publisher]
Genetic factors may impact non-alcoholic fatty liver disease (NAFLD) severity. We aimed to assess the prevalence of patatin-like phospholipase domain-containing 3 protein (PNPLA3) gene rs738409 C>G polymorphism in Brazilian type 2 diabetes individuals and to investigate its association with liver disease severity, diabetic chronic degenerative complications and metabolic control.
This article reviews studies of the target mechanisms of herbal treatments for insulin resistance.
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