Among the Severely Mentally Ill, Who Responds to Ziprasidone?

This study examines some differences in response to ziprasidone, which has been shown to be effective, with a better metabolic side effect profile, but was little used in New York State Hospitals. The aim was to study state hospital patients switched to ziprasidone. The results led to questions about different responses in different groups. Subjects from state hospitals who needed a change of antipsychotic participated in this open-label, 8-week trial of up to 240-mg ziprasidone. Analyses included comparisons of the very different results from two sites. Of the 36 study subjects, 12 terminated early. The 17 outpatients from Buffalo, who were older and on lower doses of antipsychotics pre-study, improved significantly. The 19 inpatients from the Bronx, overall younger and on higher pre-study doses, barely changed. Improvements in PANSS total score were significantly associated with older age, greater baseline severity, and lower doses of antipsychotics pre-study. The subjects improved on metabolic parameters. The results suggest that ziprasidone may be just as effective as previous antipsychotics taken by these severely mentally ill patients, and with fewer metabolic side effects. Note: The study described here includes a dosage of ziprasidone that has not been approved by the U.S. Food and Drug Administration (FDA). The FDA has approved daily doses of ziprasidone no greater than 100 mg PO bid. PMID: 30040474 [PubMed - in process]
Source: Clinical Schizophrenia and Related Psychoses - Category: Psychiatry Tags: Clin Schizophr Relat Psychoses Source Type: research

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Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 23 July 2019Source: NeuroImage: ClinicalAuthor(s): Kristin K. Lottman, Timothy J. Gawne, Nina V. Kraguljac, Jeffrey F. Killen, Meredith A. Reid, Adrienne C. LahtiAbstractSchizophrenia is often characterized by dysconnections in the brain, which can be estimated via functional connectivity analyses. Commonly measured using resting-state functional magnetic resonance imaging (fMRI) in order to characterize the intrinsic or baseline function of the brain, fMRI functional connectivity has significantly contributed to the understanding of schizophrenia. However, these measures may not capture ...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Conditions:   Schizophrenia;   Bipolar I Disorder Intervention:   Drug: Aripiprazole Sponsors:   Otsuka Pharmaceutical Development&Commercialization, Inc.;   PRA Health Sciences Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In her book Mind Fixers: Psychiatry ’s Troubled Search for the Biology of Mental Illness, historian Anne Harrington challenges psychiatrists to embrace complexity. Her central message is that society has often projected a lot onto psychiatry, with our field far too eager to accept these and to fill an expertise void: at one point, w ith psychoanalytic grandiosity, later with overpromised, underperforming biological boasts and reified diagnostic labels. Echoing Foucault, Harrington invites us to avoid mistaking the name of the thing for the thing itself and to keep struggling for answers, embracing a slow science, mar...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: Book forum Source Type: research
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Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Toxoplasma gondii, a common neurotropic parasite, is increasingly being linked to neuropsychiatric disorders, including schizophrenia, Alzheimer’s disease, and Parkinson’s disease. However, the pathogenic mechanisms underlying these associations are not clear. Toxoplasma can reside in the brain for extensive periods in the form of tissue cysts, and this process requires a continuous immune response to prevent the parasite’s reactivation. Because neuroinflammation may promote the onset and progression of neurodegenerative diseases, we investigated neurodegeneration-associated pathological changes in a mous...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Molecular Pathogenesis Source Type: research
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Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
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Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Condition:   Randomized Controlled Trial Intervention:   Other: Baduanjin program Sponsors:   National Yang Ming University;   Taipei Veterans General Hospital, Taiwan Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
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