In-vitro evaluation of cytotoxic and antioxidant properties of drugs solubilized in EO-PO star block copolymer micelles

Publication date: Available online 24 July 2018Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Urjita Sheth, Anita BahadurAbstractSelf-assembly of a biocompatible, nontoxic, commercially available star shaped polyethylene oxide-polypropylene oxide block copolymer, Tetronics®1107 (mol. wt. = 15000, % ethylene oxide = 70, and HLB 18-23) in aqueous solution was examined using surface tension, fluorescence, viscosity, cloud point and dynamic light scattering. The copolymer being very hydrophilic shows poor surface activity and forms thermo-, pH and salt responsive nanosize core-shell micelles above critical micellization temperatures. These micelles showed markedly enhanced solubilization of hydrophobic drugs curcumin and quercetin. In vitro antioxidant activities (by free radical scavenging, reducing capacity and superoxide anion radical scavenging methods) and cytotoxicity (against CHO-K1 cell line) showed desirable properties in micellar drugs as compared to free one and similar cytotoxic effects were observed for free as well as micellar drugs. This suggests T1107 as promising tool for drug delivery.Graphical abstract
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research