CaMKK2 kinase domain interacts with the autoinhibitory region through the N-terminal lobe including the RP insert

ConclusionsInteractions between the CaMKK2 kinase domain and the AID differ from those of other CaMKs. In the absence of Ca2+/CaM binding the autoinhibitory region inhibits CaMKK2 by both blocking access to the RP insert and by affecting the structure of the ATP-binding pocket.General significanceOur results corroborate the hypothesis that Ca2+/CaM binding causes unique conformational changes in the CaMKKs relative to other CaMKs.Graphical abstract

Source: Biochimica et Biophysica Acta (BBA) General Subjects - July 25, 2018 Category: Biochemistry Source Type: research