Recent findings regarding let-7 in immunity

Let-7 was one of the first microRNAs discovered in Caenorhabditis elegans. It exerts various biological functions, and shows strong evolutionary conservation from nematodes to humans. Recent research findings identify the let-7 cluster as a crucial player in the regulation of B-cell antibody production and macrophage responses. Since increasing evidence supports the let-7 cluster's role in immune system regulation, here we review the latest knowledge regarding the activities of let-7 in both innate and adaptive immune cells —including macrophages, B cells, and subsets of T cells—and the targets regulated by members of the let-7 family.
Source: Cancer Letters - Category: Cancer & Oncology Authors: Tags: Mini-review Source Type: research