Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen

Macrophages are essential to maintain tissue homeostasis. Lim and colleagues demonstrate that perivascular LYVE-1-expressing macrophages prevent arterial stiffness by controlling the expression of collagen in vascular smooth muscle cells, a process dependent on the engagement of LYVE-1 with hyaluronan on smooth muscle cells.

Source: Immunity - July 24, 2018 Category: Allergy & Immunology Authors: Hwee Ying Lim, Sheau Yng Lim, Chek Kun Tan, Chung Hwee Thiam, Chi Ching Goh, Daniel Carbajo, Samantha Hui Shang Chew, Peter See, Svetoslav Chakarov, Xiao Nong Wang, Li Hui Lim, Louise A. Johnson, Josephine Lum, Chui Yee Fong, Ariff Bongso, Arijit Biswas, Tags: Article Source Type: research