Chronic forced exercise inhibits stress-induced reinstatement of cocaine conditioned place preference.

Chronic forced exercise inhibits stress-induced reinstatement of cocaine conditioned place preference. Behav Brain Res. 2018 Jul 20;: Authors: Robison LS, Alessi L, Thanos PK Abstract Stress increases the likelihood of cocaine relapse in humans and animals, even following a prolonged extinction/abstinence period. Exercise has previously been shown to reduce stress and decrease the likelihood of drug dependence, while also reducing cravings in humans and inhibiting relapse behaviors due to other risk factors in rodents. The present study evaluated the efficacy of exercise to reduce stress-induced relapse to cocaine in a rodent model. Young adult female Sprague Dawley rats were tested for cocaine conditioned place preference (CPP), then split into sedentary or exercise (six weeks of one-hour daily treadmill running, five days per week) groups. Following cocaine CPP, rats were tested for extinction behavior, and then tested for stress-primed reinstatement (15 minute immobilization) following the six-week intervention period. Exercise inhibited stress-induced reinstatement of cocaine CPP despite increasing serum corticosterone levels following 15 minutes of immobilization, suggesting that chronic aerobic exercise intervention may result in adaptations of stress pathways. These findings suggest that exercise may help prevent stress-induced drug relapse, adding to a growing body of evidence supporting the utility of exercise to combat substance a...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

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Conclusions: Our study sample described long-term recovery as a developmental process from dependency and reactivity to personal autonomy and self-agency. The flux of surrendering to and differentiating from authority appeared to be a driving force in recovery progression. Participants called for treatment to focus on early social readjustment.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Being a survivor of suicide loss is a unique kind of grief. In the realm of mental health stigma, suicide is about as nightmare as you can get.  A survivor of suicide loss endures many days of bewilderment. While the momentum of episodic depression, anxiety, and substance abuse that often precedes suicide comes to a screeching halt for your loved one in their death, the hurricane force winds rage on for the survivor, now compiled with even more pain, confusion, and grief, as you process the sudden loss of your loved one.  In addition to your own sense of loss, you are forced to come up with euphemisms to describe...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Grief and Loss Suicide Bereavement grieving National Suicide Prevention Awareness Month Source Type: blogs
Funding Opportunity RFA-DA-20-026 from the NIH Guide for Grants and Contracts. The scientific objective of this Funding Opportunity Announcement is to encourage research to delineate the role of inflammasomes in the neuropathology produced by acute or chronic drug exposure and HIV infection. Understanding the involvement of inflammasomes in virus and drug-induced immune activation may help identify molecular markers and CNS immune cells associated with HIV-1 infection or disease progression among substance abuse populations, as well as identify novel therapies to target inflammasome activation or suppression to treat neur...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
BACKGROUND: Pavlovian-to-instrumental transfer (PIT) describes the influence of conditioned stimuli on instrumental behaviors and is discussed as a key process underlying substance abuse. Here, we tested whether neural responses during alcohol-related PIT ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Sep 26, 2019. SAMHSA Headquarters, Rockville, MD. Sponsored by Substance Abuse and Mental Health Services Administration
Source: Rural events via the Rural Assistance Center - Category: Rural Health Source Type: events
CONCLUSION: The importance of perceived provider empathy and the patient's social connectedness in SUD interventions was underscored as incentives for participation and retention, providing valuable information for the implementation of MBIs among patients recovering from SUD. PMID: 31519269 [PubMed - in process]
Source: Complementary Therapies in Medicine - Category: Complementary Medicine Authors: Tags: Complement Ther Med Source Type: research
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