Prevalence and molecular characteristics of defective mismatch repair epithelial ovarian cancer in a Japanese hospital-based population

ConclusionsThe prevalence of defective mismatch repair epithelial ovarian cancer in the Japanese hospital-based population was extremely low. Molecular mechanism involved in such defective mismatch repair ovarian cancers seems to be epigenetic events throughMLH1 promotor hypermethylation or somatically mutated mismatch repair genes without germline mismatch repair mutation.
Source: Japanese Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research