Investigation of the mtDNA mutations in Syrian Families With Non-Syndromic Sensorineural Hearing Loss

Hearing loss is a common sensory disorder, and at least 50% of cases are due to a genetic etiology. Several mitochondrial DNA mutations (mtDNA) have been reported to be associated with nonsyndromic hearing loss (NSHL) in different population. However, There is no previous available data about the frequency of mtDNA mutations as etiology for deafness in Syrian. The aim of present study is to investigate the incidence of common mt DNA mutations in our families with congenital hearing loss and not related to the ototoxicity or aminoglycosides.

Source: International Journal of Pediatric Otorhinolaryngology - July 23, 2018 Category: ENT & OMF Authors: Faten Moassass, Bassel AL-Halabi, Mohamad Sayah Nweder, Walid AL-Achkar Source Type: research