Errata

We describe a case report of a rare cancer affecting the kidney of 63 years of age patient who underwent imaging studies from ultrasound, computed tomography, and magnetic resonance imaging, due to complaints: left back pain and urinary obstruction. Sonographic and radiological features of the mass found suggested the diagnosis of a malignant tumor of parenchymal origin. The pathological and immunohistochemical studies of the resected anatomical specimen, however, diagnosed a rare benign variant of solitary fibrous tumor originating in the inferior pole of the left kidney.Descrevemos o relato de caso de uma rara neoplasia acometendo o rim de um paciente de 63 anos de idade que foi submetido a estudos de imagem por ultrassonografia, tomografia computadorizada e ressonância magnética nuclear devido às queixas apresentadas: dor lombar à esquerda e alterações miccionais sugestivas de obstrução infravesical. As características ultrassonográficas e radiológicas da massa encontrada sugeriam o diagnóstico de uma neoplasia maligna de origem parenquimatosa. O estudo anatomopatológico e imuno-histoquímico da peça anatômica ressecada, entretanto, concluiu o quadro como variante benigna do raro tumor fibroso solitário originário do polo inferior do rim esquerdo.
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research

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ConclusionThe surgical treatment of postirradiation kyphotic spinal deformity is challenging, with common postoperative complications such as infection, instrumentation failure, and pseudarthrosis. However, with modern surgical techniques and spinal instrumentation, excellent deformity correction can be achieved and maintained. We recommend performing a two-stage procedure for cervicothoracic deformity, with anterior release followed by posterior fusion and instrumentation. In thoracolumbar deformities, correction can be achieved through single-stage posterior fusion. Rigid spinopelvic fixation with sacral-alar-iliac screw...
Source: Spine Deformity - Category: Orthopaedics Source Type: research
This article highlights the importance of patient education and cautious opioid prescribing in patients with cancer.Implications for Practice.The current opioid crisis makes it challenging to effectively manage cancer pain. Providers play a prominent role in minimizing opioid misuse. Cautious prescribing with limits enforced on the quantity of opioids prescribed, close follow‐up, and consistent and frequent provision of opioid education are a must. Evidence points to the impact of patient education in promoting safety around opioid use. Most people who misuse prescription opioids obtain them from family or friends. Stori...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Symptom Management and Supportive Care Cancer Care and the Opioid Crisis Source Type: research
Publication date: Available online 11 November 2019Source: Neuroscience LettersAuthor(s): Bingjie Qin, Yuxing Li, Xiaohu Liu, Denghui Gong, Weihong ZhengAbstarctChemotherapy-induced peripheral neuropathy (CIPN) has a adverse impact to the living quality of cancer patients. This side effect of CIPN limit the dose of drug used in many chemotherapies, such as vincristine (VCR). The activation of microglia in the spinal dorsal horn is involved in the occurrence and development of neuropathic pain induced by VCR. Recent study has demonstrated that hypoxia induced microglia activation depends on Notch signaling, and it is involv...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
In this study, we measured the analgesic effects of different intrathecal doses of SRT1720 on BCP in a murine model and further examined whether SRT1720 attenuated BCP by suppressing CREB/CREB-regulated transcription coactivator 1 (CRTC1) signalling pathway. Our results demonstrated that the BCP mice developed significant mechanical allodynia and spontaneous flinching, which were accompanied by the upregulation of phospho-Ser133 CREB (p-CREB) and CRTC1 expression in the spinal cord. SRT1720 treatment produced a dose-dependent analgesic effect on the BCP mice and downregulated the expression of p-CREB and CRTC1. These resul...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Conclusions: IPMT is potentially feasible for high-risk USM patients. Future trials adequately powered for relevant endpoints are thus recommended.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
The original version of this article unfortunately contained a mistake in Fig. 2.
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
This study investigated the role of SAP102 in the formation of hyperalgesia in rats with CIBP SAP102 is present in spinal dorsal horn neurons, but not in astrocytes or microglia. NMDAR-NR2B is localized with neurons. In addition, SAP102 and NMDAR-NR2B expression levels in spinal dorsal horn tissues were detected by Western blot and co-immunoprecipitation. Intrathecal injection of lentiviral vector of RNAi to knockdown SAP102 expression in the spinal dorsal horn significantly attenuated abnormal mechanic pain when compared to non-coding lentiviral vector. These findings indicate that SAP102 can anchor NMDA receptors to affe...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Lois Parker, of Hatfield, Hertfordshire, was told she had neuroblastoma in September 2018. The cancer affects just 100 children in the UK a year, but Ms Parker was 19.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conclusion: The survival benefits of abiraterone and enzalutamide for CRPC were evident and promising, while the risk of AE occurrence was also acceptably higher in the treatment group than in the placebo group.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
AbstractIntroductionTo evaluate the long-term consolidation of vertebral metastases (VM) after preventive vertebroplasty (PV) and to report risk factors of pathological fracture despite PV.Materials and MethodsFiles of 100 consecutives cancer patients referred for PV of VM were retrospectively analyzed. We enumerated 215 VM at the time of the PV procedure (T0): 138 VM were considered at risk of pathological fracture and had PV (treated-VM), and 77 VM were not cemented. We compared the VM characteristics using the spine instability neoplastic score (SINS) at T0 and the rate of pathologic fracture between treated-VM and untr...
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research
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