Clinical implications and histological correlation of atypical glandular cells found in cervicovaginal smears

Conclusion: Our results reinforce the importance of adequate follow-up of patients with AGC diagnosis on cervical cytology. Introdução: Células glandulares atípicas (CGA) são portadoras de alterações nucleares insuficientes para o diagnóstico de adenocarcinoma, mas excedem os critérios para classificação como células glandulares reacionais. Trata-se de um diagnóstico incomum, porém pode relacionar-se com lesões neoplásicas. Objetivo: Avaliar o significado clínico do diagnóstico citológico primário indicando CGA por meio da correlação com os resultados de exames histológicos subsequentes. Materiais e métodos: Estudo retrospectivo de 10 anos com base em resultados colpocitológicos indicando CGA, classificados como "possivelmente não neoplásicas" ou "não se pode afastar lesão intraepitelial de alto grau". Realizou-se a correlação cito-histopatológica nos casos que foram submetidos ao exame histopatológico até dois anos após a análise colpocitológica. Resultados: CGA foram relatadas em 380 (0,06%) exames, dispondo-se de 160 casos com biópsia subsequente. Destes, 85 (53,1%) apresentavam alterações benignas e 75 (46,9%), lesões neoplásicas. Dos 114 resultados citol&oacut...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research

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CONCLUSION: Endometrial cancer patients with abnormalPap smears were strongly and independently associated with histopathologically diagnosed cervical stromal invasion. PMID: 31554386 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Background: Lower genital tract carcinomas that coexist with genitourinary malformations are rare. The aim of this study was to investigate the clinicopathologic characteristics and outcomes of patients with this rare joint condition. The aim of this study was to investigate the clinicopathologic characteristics and outcomes of these patients to analyze the associations among clinicopathologic features in this rare entity.Methods: The medical records of patients with carcinoma of lower genital tract combined with genital tract malformations who were treated at Peking Union Medical College Hospital (Beijing, China) between ...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
We report a case of misdiagnosed endometrial cancer by D&C, but with a positive cytopathological finding. Following that, a meta-analysis including 4,179 patients of endometrial diseases with cyto-histopathological results was performed to assess the value of the endometrial cytological method in endometrial cancer diagnosis. The pooled sensitivity and specificity of the cytological method in detecting endometrial atypical hyperplasia or cancer was 0.91[95% confidence interval (CI) 0.74–0.97] and 0.96 (95% CI 0.90–0.99), respectively. The pooled positive likelihood ratio and negative likelihood ratio was 25.4 (...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: The rate of significant histopathologies among women with ASC-H smears in this study was approximately 31% and the associated risk factor was patient age. PMID: 30909664 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
ConclusionEvaluation of cases of perimenopausal and postmenopausal bleeding differentiated premalignant and malignant lesions of the uterine body, endometrium and cervix. As our centre is a Regional Cancer Centre of Bihar, incidence of malignant lesions is higher in our centre.
Source: The Journal of Obstetrics and Gynecology of India - Category: OBGYN Source Type: research
Conclusions: LBC enhanced cotesting detection of CxCa and CIN3/AIS to a greater extent than previously reported with conventional Pap smear and HPV cotesting. PMID: 30137189 [PubMed - as supplied by publisher]
Source: American Journal of Clinical Pathology - Category: Pathology Authors: Tags: Am J Clin Pathol Source Type: research
Conclusions: Yellow mucin is a diagnostic clue for endocervical glandular lesions with gastric differentiation. We recommend describing AEC-GAM on cytologic reports to improve cytologic screening for HPV-negative cervical cancers. PMID: 29982289 [PubMed - as supplied by publisher]
Source: American Journal of Clinical Pathology - Category: Pathology Authors: Tags: Am J Clin Pathol Source Type: research
Abstract Human papillomavirus infection is the precursor for the development of cervical cancer and is detectable in 99.7% of squamous cell carcinoma and adenocarcinoma cases. Early detection of precancerous lesions with Papanicolaou testing remains the primary mechanism for cancer prevention. Once cervical cancer is diagnosed, treatment may involve surgery, radiation therapy, chemotherapy, or a combination. The choice of therapy depends on the stage of disease, lymph node involvement, patient comorbidities, and risk factors for recurrence. Early-stage, microinvasive disease may be treated with surgery alone if ma...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
Atypical glandular cells are gynecologic cytology abnormalities representing glandular cells with morphologic changes that exceed obvious reactive/reparative changes, but fall short of an interpretation of adenocarcinoma either quantitatively or qualitatively. This cytological diagnosis occurs in less than 1% of the results of gynecologic cytology tests (0.2%–0.8%) but potentially reflects a wide range of conditions, from benign changes and cervical squamous/glandular precursor lesions, to invasive cervical or other gynecologic cancers. In this article, we aim at reviewing different subcategories, potential ancillary...
Source: Pathology Case Reviews - Category: Pathology Tags: Case Reviews Source Type: research
The national cervical screening programme, CervicalCheck, commenced in Ireland in 2008. Free cervical smear tests are offered to over 1.2 million women aged 25–60 every 3 (aged 25–44) and 5 (aged 45–60) years. The purpose of this paper is to highlight the achievements and document the experience of the first 6 years of a new cervical screening programme. Data were extracted from the programme screening register and colposcopy management systems. SAS, version 9.4 was used for statistical analysis. Over 1.98 million smear tests were performed in over 1 million women during the first 6 years of the programme...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Research Papers: Gynecological Cancer Source Type: research
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