Metformin Alleviates Radiation-Induced Skin Fibrosis via the Downregulation of FOXO3

Conclusions: The results indicated that metformin suppresses radiation-induced skin injuries by modulating the expression of FOXO3 through PIK3r1. Collectively, the data obtained in this study suggested that metformin could be a potent therapeutic agent for alleviating radiation-induced skin fibrosis.Cell Physiol Biochem 2018;48:959 –970

https://www.karger.com/Article/FullText/491964

Source: Cellular Physiology and Biochemistry - July 23, 2018 Category: Cytology Source Type: research