Changes in biomarkers serum amyloid A and haptoglobin following treatment of endometritis in dairy cows

AbstractMonitoring of changes in acute phase proteins following the treatment of endometritis can help us to improve treatment protocols. In total, 81 dairy cows affected by clinical endometritis were selected in 30  days in milk (DIM) and treated with hyperimmune serum. Cervical mucus cytology was used to determine the neutrophil percentage. Levels of amyloid A (SAA) and haptoglobin (Hp) in blood serum were measured just before and 2 weeks after the treatment. The cows were timed-inseminated with Heat Synch following the treatment, and pregnancy was diagnosed 35 ± 3 days after AI. Variables such as parturition (abnormal and normal), 305 days milk production, pregnancy status, number of AI, endometritis score, days open, and parity were considered in statistical analysis. Concentrations of SAA an d Hp were significantly lower after the treatment of cows affected by endometritis (P   100 days. The results showed a positive significant correlation (r = 0.44,P = 0.02) between SAA and Hp in pre-treatment cows, but this correlation was not significant after the treatment (r = 0.01,P = 0.98). Treatment of cows affected by clinical endometritis with hyperimmune serum could decrease SAA and Hp, and factors such as milk production, pregnancy status, and days open affected their concentrations.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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