Rosmarinic acid reverses the deleterious effects of repetitive stress and tat protein.

Rosmarinic acid reverses the deleterious effects of repetitive stress and tat protein. Behav Brain Res. 2018 Jul 17;: Authors: Makhathini KB, Mabandla MV, Daniels WMU Abstract Human immunodeficiency virus type 1 (HIV) has infected more than 40 million people worldwide and is associated with central nervous system (CNS) disruption in at least 30% of these persons. The use of highly active antiretroviral therapy (HAART) has significantly reduced the systemic immunopathology associated with HIV, but the occurrence of neurological disorders continues to be reported in notable numbers. The present study evaluated the potential of rosmarinic acid to reverse the detrimental effects of an intracerebral injection of the viral protein tat. Control and tat-injected rats were also subjected to repetitive restrain stress (RRS) for 28 days, 6 hours per day, to investigate whether subsequent stress exposure would worsen the effects of tat. 14 days after the initiation of RRS, animals were treated with rosmarinic acid (10 mg/kg given intraperitoneally) daily until the end of the stress exposure period. We assessed locomotor activity and anxiety-like behavioral changes. We also measured plasma corticosterone levels and quantified the expression of mineralocorticoid receptors (MR), glucocorticoid receptors (GR) and brain-derived neurotrophic factor (BDNF) in the hippocampus. Rosmarinic acid attenuated anxiety-like behavior induced by tat and stress, reduced ...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

Related Links:

Objective: Social anxiety and depression are commonly comorbid and cause significant impairment in college students. Past research suggests that both poor attentional control and increased rumination are related to these disorders and independently ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
The current study examined prospective bidirectional links between dysregulated sleep, and anxiety and depression severity across 4  years, among youth with a history of anxiety disorder. Participants were 319 youth (age 11-26 years), who previously parti...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
By offering full tuition, medical schools hope to relieve financial anxiety and reshape the physician workforce. Although it's early, some impacts of this change are already being seen.Medscape Med Students
Source: Medscape Med Students Headlines - Category: Universities & Medical Training Tags: Med Students Article Source Type: news
ConclusionsDespite heterogeneity of outcomes across studies, there is evidence that brief MBIs can impact numerous health-related outcomes, after only one session and with interventions as brief as 5  min. These interventions have the potential to be the initial steps leading to sustainable and positive health outcomes.
Source: Mindfulness - Category: Psychiatry & Psychology Source Type: research
In road rage, small infractions can easily escalate to disproportionate responses. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Social psychology subscribers-only Source Type: blogs
The food signals the body to start burning fat and stop storing it. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Weight Loss Source Type: blogs
Abstract INTRODUCTION: The Islamic State in Iraq and Syria (ISIS) attacked Sinjar, a majority Yezidi region, on 3 August 2014. ISIS fighters systematically and deliberately targeted the Yezidi Kurdish population. Several of the region's women and girls were abducted, raped, sold and gifted to other ISIS fighters in Iraq and Syria. Amnesty International claims that the women and girls who survived ISIS captivity, or who succeeded in escaping the attack, suffer from severe psychiatric disorders, such as depression and anxiety. This paper discusses the effectiveness of a two-month art-based intervention course on the...
Source: Complementary Therapies in Medicine - Category: Complementary Medicine Authors: Tags: Complement Ther Med Source Type: research
Publication date: Available online 14 September 2019Source: Reumatología Clínica (English Edition)Author(s): Manuel Jiménez Ortiz, Alfonso Espinosa Ruiz, Cristóbal Martínez Delgado, Pablo Barrena Sánchez, José A. Salido ValleAbstractBackgroundThe association of depression and chronic pain in knee osteoarthritis is a complex and difficult phenomenon to understand. In fact, establishing the order of appearance of these entities might result in an arduous task.ObjectiveIn addition to analysing the relationship between preoperative anxiety and depression according to the results...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
Discussion Benign fasciculations are very common and occur in up to 70% of the general population. They occur at different points in people’s lives. They can be brought out by stress, poor sleep hygiene and caffeine. Caffeine has numerous uses especially for regulating sleep and attention. However too much can cause restlessness, jitteriness and sleep deprivation too. The recommended amount of caffeine for a teenager is
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
ConclusionPerforming chromosomal microarray on a structurally normal fetus and identifying abnormal copy number variants may give the parents enough information for deciding on the further course of the pregnancy.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
More News: Anxiety | Brain | Highly Active Antiretroviral Therapy | Neurology | Study