Sirt1 mediates improvement of isoflurane-induced memory impairment following hyperbaric oxygen preconditioning in middle-aged mice

Publication date: Available online 21 July 2018Source: Physiology &BehaviorAuthor(s): Hu Hong-qiang, Shu Mang-qiao, Xue Fen, Liu Shan-shan, Cao Hui-juan, Hou Wu-gang, Yan Wen-jun, Peng Zheng-wuAbstractHyperbaric oxygen (HBO) preconditioning (PC) has been suggested as a feasible method to provide neuroprotection from postoperative cognitive dysfunction (POCD). However, whether HBO-PC can ameliorate cognitive deficits induced by isoflurane, and the possible mechanism by which it may exert its effect, has not yet been clarified. In the present study, middle-aged mice were exposed to isoflurane anesthesia (1.5 minimal alveolar concentration [MAC]) for 2 h to establish a POCD model. After HBO preconditioning, cognitive function and expression of hippocampal sirtuin 1 (Sirt1), nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) were evaluated 24 h following isoflurane treatment, in the presence or absence of Sirt1 knockdown by short hairpin RNA (shRNA). HBO preconditioning increased the expression of Sirt1, Nrf2, and HO-1 and ameliorated memory dysfunction. Meanwhile, Sirt1 knockdown inhibited the expression of Nrf2 and HO-1 and attenuated the HBO preconditioning-associated memory improvement. Our results suggest that the application of HBO preconditioning is a useful treatment for POCD, and that Sirt1 may be a potential molecular target for POCD therapy.
Source: Physiology and Behavior - Category: Physiology Source Type: research

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Purpose of review To identify and discuss emerging trends in the therapeutic use of hyperbaric oxygen. Recent findings There has been a maturing of the clinical evidence to support the treatment of sudden hearing loss, a wide range of problematic chronic wound states and the prevention and treatment of end-organ damage associated with diabetes mellitus. On the other hand, the controversy continues concerning the use of hyperbaric oxygen therapy (HBOT) to treat sequelae of mild traumatic brain injury. HBOT remains poorly understood by many medical practitioners despite more than 50 years of clinical practice. Pharmacol...
Source: Current Opinion in Anaesthesiology - Category: Anesthesiology Tags: TECHNOLOGY, EDUCATION AND SAFETY: Edited by Stephan A. Loer Source Type: research
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Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
(Reg Anesth Pain Med. 2018;43(8):885–889) Spinal-induced hypotension is a common problem resulting from the sympathectomy associated with the administration of intrathecal local anesthetic for cesarean delivery, and is associated with nausea, vomiting, loss of consciousness, impaired fetal oxygenation, and fetal acidosis. Prophylactic phenylephrine infusion is often used to decrease the risk of spinal-induced hypotension; however, its use has been associated with decreased rostral spread of intrathecal local anesthetic in pregnancy. The purpose of this study was to determine the median effective dose (ED50) and 95% ...
Source: Obstetric Anesthesia Digest - Category: Anesthesiology Tags: Anesthesia and Analgesia: Regional Anesthesia Source Type: research
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Source: Der Anaesthesist - Category: Anesthesiology Authors: Tags: Anaesthesist Source Type: research
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Source: Frontiers in Physiology - Category: Physiology Source Type: research
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Source: Der Anaesthesist - Category: Anesthesiology Authors: Tags: Anaesthesist Source Type: research
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Source: Adv Data - Category: Epidemiology Authors: Tags: Adv Exp Med Biol Source Type: research
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Source: Journal of Clinical Anesthesia - Category: Anesthesiology Authors: Tags: Correspondence Source Type: research
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Source: Undersea and Hyperbaric Medicine - Category: Sports Medicine Authors: Tags: Undersea Hyperb Med Source Type: research
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Source: Acta Cirurgica Brasileira - Category: Surgery Authors: Tags: Acta Cir Bras Source Type: research
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