Impact of Potassium Citrate vs. Citric Acid on Urinary Stone Risk in Calcium Phosphate Stone Formers

No medication has been shown to be effective at preventing recurrence of calcium phosphate urinary stones. Potassium citrate may protect against calcium phosphate stones by enhancing urine citrate excretion and lowering urine calcium, but it raises urine pH which increases calcium phosphate saturation and may negate the beneficial effects. Citric acid can potentially raise urine citrate but not pH, and thus may be a useful countermeasure against calcium phosphate stones. We aimed to assess whether these two agents can significantly alter urine composition and reduce calcium phosphate saturation.

Source: The Journal of Urology - July 20, 2018 Category: Urology & Nephrology Authors: Steeve Doizi, John R. Poindexter, Margaret S. Pearle, Francisco Blanco, Orson W. Moe, Khashayar Sakhaee, Naim M. Maalouf Source Type: research