Prognostic and predictive values of immune infiltrate in patients with head and neck squamous cell carcinoma

This study sought to determine whether the in situ tumor-infiltrating immune lymphocytes, as a novel companion to the Immunoscore analysis, could be a promising, valuable prognostic and predictive marker in patients with head and neck squamous cell carcinoma (HNSCC). Total (CD3+) and cytotoxic (CD8+) T lymphocytes were assessed using immunohistochemistry in tumor nests and stroma obtained from patient surgical specimens. The “Immunoscore” methodology has been defined to quantify the amount of in situ immune infiltrate (from I0 to I4).

Source: Human Pathology - July 20, 2018 Category: Pathology Authors: Xue-Mei Zhang, Ling-Jun Song, Juan Shen, Hao Yue, Ya-Qin Han, Chen-Ling Yang, Shi-Yun Liu, Jia-Wen Deng, Yue Jiang, Guo-Hui Fu, Wei-Wei Shen Tags: Original contribution Source Type: research