Extracts of Cerbera manghas L. effectively inhibit the viability of glioblastoma cell lines and their cancer stemloids in vitro and in mouse xenograft model

In this study, neriifolin effectively inhibited the growth and colony formation of CD133+ GBM tumorspheres. Both C. manghas extracts and neriifolin inhibited Akt activation and caused cell cycle G1 arrest. They also reduced the expression of the stem cell marker Sox2. Treatment with their higher doses induced the apoptosis of GBM tumorspheres. Furthermore, neriifolin inhibited the growth of CD133+ GBM tumorsphere-derived tumors in vivo. In summary, neriifolin obtained from extracts of C. manghas may serve as a drug lead compound for GBM therapies.Graphical abstract
Source: Journal of Functional Foods - Category: Nutrition Source Type: research