Ormosanine from Akebia quinata suppresses ethanol-induced inflammation and apoptosis and activates antioxidants via the mitogen activated protein kinase signaling pathway

In this study, we evaluated whether ormosanine from AQ exhibited antioxidant, anti-inflammatory, or anti-apoptotic effects in a rat model of ethanol-induced liver injury. The protective activities of ormosanine against ethanol toxicity in the liver include the suppression of acetaldehyde through activation of ALDH2 and suppression of CYP2E1. Our study shows that ormosanine protects against ethanol-induced liver injury by reducing the expression of inflammatory regulators (COX-2, TNF-α, and IL-6), and apoptosis-associated protein (p53, Bax, cytochrome C, procaspase-3, PARP-1) via activating the p-AKT and MAPK (p-ERK, and p-JNK) signaling pathways. Therefore, ormosanine plays an important role as a free radical-scavenger and may help prevent as well as alleviate ethanol-induced liver injury.
Source: Journal of Functional Foods - Category: Nutrition Source Type: research