Rutin protects t-butyl hydroperoxide-induced oxidative impairment via modulating the Nrf-2 and iNOS activity

Conclusion: Our findings demonstrate that rutin potentiates its beneficial aspect by displaying a profound role in iNOS-Nrf-2 signaling pathway. Accordingly, it may be concluded that the dietary factors wherein rutin is an ingredient could be helpful in the maintenance of intracellular redox-homeostasis and thus may be effective against oxidative stress related sondary complications.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research