Immune cell census in murine atherosclerosis: cytometry by time of flight illuminates vascular myeloid cell diversity

ConclusionsA CyTOF-based comprehensive mapping of the immune cell subsets within atherosclerotic aortas from ApoE−/− mice offers tools for myeloid cell discrimination within the vascular compartment and it reveals that high fat feeding skews the myeloid cell repertoire toward inflammatory monocyte-macrophage populations rather than resident macrophage phenotypes and cDC2 during atherogenesis.
Source: Cardiovascular Research - Category: Cardiology Source Type: research