Scientific updates on the interaction of genes, epigenetics, and multicellularity in cardiovascular diseases: the Working Group of Myocardial Function of the ESC

Myocardial diseases such as myocardial infarction are directly linked to vascular pathology including endothelial dysfunction, inflammation, and thrombosis. Also in heart failure with reduced or with preserved ejection fraction, macro- and microvascular dysfunction either in the heart itself but also in the periphery is directly or indirectly related to myocardial hypertrophy, remodelling, and progression of heart failure. Multicellularity in the heart and vascular system and countless variable cell –cell interactions at all levels contribute to cardiovascular (patho)physiology. Interactions e.g. of cardiomyocytes with fibroblasts, but also with endothelial cells, myeloid cells, and lymphoid cells render the understanding of pathogenesis and the development of treatments for cardiomyopathies exceedingly complex.
Source: Cardiovascular Research - Category: Cardiology Source Type: research