Csp3-H bond functionalization of amines via tunable iminium ions: divergent synthesis of trifluoromethylated arylamines.

Csp3-H bond functionalization of amines via tunable iminium ions: divergent synthesis of trifluoromethylated arylamines.
Chem Commun (Camb). 2018 Jul 19;:
Authors: Shi L, Wang M, Pan L, Li Y, Liu Q
Abstract
A series of tunable iminium ions, generated in situ by the condensation of 4-trifluoromethyl-p-quinols with cyclic amines, can lead to the divergent synthesis of trifluoromethylated arylamines in a single step via redox-neutral isomerization. The direct α- and β-functionalization of saturated amines can be achieved regioselectively under mild conditions.
PMID: 30024583 [PubMed - as supplied by publisher]

Source: Chemical Communications - July 19, 2018 Category: Chemistry Authors: Shi L, Wang M, Pan L, Li Y, Liu Q Tags: Chem Commun (Camb) Source Type: research