Pharmacological application of barium containing bioactive glass in gastro-duodenal ulcers

Publication date: 1 November 2018Source: Materials Science and Engineering: C, Volume 92Author(s): Pankaj Paliwal, Arepalli Sampath Kumar, Himanshu Tripathi, S.P. Singh, Shashikant C.U. Patne, Sairam KrishnamurthyAbstractPeptic ulcer is prevalent in about 4% of the world population and nearly 10% of people have been affected by peptic ulcer at some point in their life. Therefore, there is a need for newer efficient and safe anti-ulcer agents. In the present strategy, we have prepared a novel bioactive glass containing 1.3 mol% of barium oxide (BaBG) and evaluated its antiulcer potential in gastroduodenal ulcer models. Prophylactic effect of BaBG pretreatment was evaluated for 5 days in ethanol, aspirin and pyloric ligation-induced gastric ulcer and cysteamine-induced duodenal ulcer models. Repeated treatment of 10 days of BaBG was evaluated in the healing ulcer model of acetic acid. BaBG significantly reduced the ulcerative damage against all the five tested ulcer models. Scanning electron microscope (SEM) images have shown that BaBG forms a physical protective barrier over the gastro-duodenal epithelium cell. In the pyloric-ligation, ethanol and aspirin models, BaBG showed significantly increased in gastric pH, indicating antacid like activity. BaBG treatment significantly increased cell proliferation in the pyloric model. Thus, BaBG mediates antiulcer action by forming a protective physical barrier against harsh luminal factors, acid neutralization and cell proliferat...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research

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Peptic ulcer disease affects 10% of men and 4% of women in the United States at some time in their lives. A peptic ulcer is a mucosal break of greater than or equal to 3 mm in size with depth, that can involve the stomach (gastric ulcer) or duodenum (duodenal ulcer).
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Resource Center Source Type: news
CONCLUSION: Over the 23 years studied, the causes of NVUGB changed, probably because the population was increasingly elderly population and because of the use of anticoagulants and better therapeutic approaches to chronic duodenal ulcers. The use of emergency surgical hemostasis reduced, but mortality rate did not significantly change between the two specific periods. PMID: 31258140 [PubMed - as supplied by publisher]
Source: The Turkish Journal of Gastroenterology - Category: Gastroenterology Authors: Tags: Turk J Gastroenterol Source Type: research
ConclusionsThe results support the premise that stroke may be associated with a history ofH  pylori infection.
Source: Helicobacter - Category: Gastroenterology Authors: Tags: ORIGINAL ARTICLE Source Type: research
CONCLUSION: Our finding supports previous reports on the damaging effect of environmental noise on the gastrointestinal tract and suggests that cumulative exposure to environmental nighttime noise affects the development of peptic ulcers. PMID: 30366660 [PubMed - as supplied by publisher]
Source: Environment International - Category: Environmental Health Authors: Tags: Environ Int Source Type: research
CONCLUSION: Our study shows that the interaction between the type of infectious strain and the Th1 immune response can influence and perpetuate gastric inflammation, and thus contributes to the development of the different clinical manifestations of H. pylori infection.RESUMO CONTEXTO: A associa ção da infecção por Helicobacter pylori com diferentes doenças gastroduodenais pode estar associada a fatores bacterianos, do hospedeiro e do ambiente. Nesse contexto, estudos têm demonstrado que a diversidade genética do H. pylori, sobretudo nos genes vacA e cagA, está associa...
Source: Arquivos de Gastroenterologia - Category: Gastroenterology Source Type: research
In conclusion, PUB is the main cause of UGIB, characterized by a significant rebleeding rate and mortality. PMID: 29590726 [PubMed - in process]
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
CONCLUSION: In the present study, there was no association of H. pylori in patients with RAS and in patients with RAS along with gastric ulcers. CLINICAL SIGNIFICANCE: This clinical study evaluated the relation of H. pylori in RAS patients. PMID: 29208798 [PubMed - in process]
Source: J Contemp Dent Pract - Category: Dentistry Authors: Tags: J Contemp Dent Pract Source Type: research
Abstract BackgroundAside from Helicobacter pylori, another cause for the development or worsening of gastrointestinal ulcers is scrub typhus, an acute febrile disease caused by Orientia tsutsugamushi. We aimed to compare the endoscopic characteristics of peptic ulcers caused by these infectious agents. MethodsThis retrospective case‐control study involved patients who underwent upper gastrointestinal endoscopy at Chosun University Hospital in Korea. We compared endoscopic features and demographic characteristics between patients with H. pylori infection and those with O. tsutsugamushi infection. ResultsA total of 14...
Source: Helicobacter - Category: Gastroenterology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusions. A 10-day triple therapy containing ilaprazole, levofloxacin, and amoxicillin is a safe alternative first-line eradication treatment for H. pylori. PMID: 28539935 [PubMed - in process]
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Abstract The serum pepsinogen (PG) assay findings are correlated with the status of Helicobacter pylori infection, but there are controversies on the link with upper gastrointestinal (UGI) endoscopic findings. The aim of this study was to determine the significance of a serum PG assay for correlating with endoscopic findings in H. pylori-seroprevalent adult population. Korean adults who visited for a health check-up were included consecutively. Subjects after gastrectomy or H. pylori eradication were excluded. After completing the serum PG assay and anti-H. pylori immunoglobulin G (IgG) titer on the same day of UG...
Source: J Korean Med Sci - Category: Journals (General) Authors: Tags: J Korean Med Sci Source Type: research
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