Molecules, Vol. 23, Pages 1799: Induction of Different Sensitization Patterns of MRSA to Antibiotics Using Electroporation

Molecules, Vol. 23, Pages 1799: Induction of Different Sensitization Patterns of MRSA to Antibiotics Using Electroporation Molecules doi: 10.3390/molecules23071799 Authors: Vitalij Novickij Jurgita Švedienė Algimantas Paškevičius Svetlana Markovskaja Eglė Lastauskienė Auksė Zinkevičienė Irutė Girkontaitė Jurij Novickij Treatment of bacteria-associated infections is complicated and antibiotic treatment alone is often inadequate to overcome biofilm infections. Physical methods allow overcoming this problem and propose solutions that are non-dependent on drug resistance. In this work, we investigated the feasibility of pulsed electric fields for sensitization of MRSA to common antibiotics. We analyzed the efficacy of inactivation of methicillin-resistant Staphylococcus aureus in 5–20 kV/cm electric field separately and in combination with gentamicin, doxycycline, ciprofloxacin, sulfamethoxazole, and vancomycin. Combined treatment allowed using up to 1000-fold smaller concentrations of antibiotics to induce the same inactivation of S. aureus.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research