Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Publication date: Available online 20 July 2018Source: The Lancet HaematologyAuthor(s): Carolyne M Ndila, Sophie Uyoga, Alexander W Macharia, Gideon Nyutu, Norbert Peshu, John Ojal, Mohammed Shebe, Kennedy O Awuondo, Neema Mturi, Benjamin Tsofa, Nuno Sepúlveda, Taane G Clark, Gavin Band, Geraldine Clarke, Kate Rowlands, Christina Hubbart, Anna Jeffreys, Silvia Kariuki, Kevin Marsh, Margaret MackinnonSummaryBackgroundHuman genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms—many related to the structure or function of red blood cells—and risk for severe Plasmodium falciparum malaria and its specific phenotypes, including cerebral malaria, severe malaria anaemia, and respiratory distress.MethodsWe did a case-control study in Kilifi County, Kenya. We recruited as cases children presenting with severe malaria to the high-dependency ward of Kilifi County Hospital. We included as controls infants born in the local community between Aug 1, 2006, and Sept 30, 2010, who were part of a genetics study. We tested for associations between a range of candidate malaria-protective genes and risk for severe malaria and its specific phenotypes. We used a permutation approach to account for multiple comparisons between polymorphisms and severe malaria. We judged p values less than 0·005 significant for the primary analysis of the association between candidate genes and severe malaria.Findings...
Source: The Lancet Haematology - Category: Hematology Source Type: research

Related Links:

[East African] The Global Fund, the body that finances the world's HIV, tuberculosis (TB) and malaria programmes, has given Kenya Ksh42 billion ($420 million) to cover the intervening years to 2024.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Hereditary hemorrhagic telangiectasia (HHT), a genetic bleeding disorder leading to systemic arteriovenous malformations (AVMs), is caused by loss-of-function mutations in the ALK1/ENG/Smad1/5/8 pathway. Evidence suggests that HHT pathogenesis strongly relies on overactivated PI3K/Akt/mTOR and VEGFR2 pathways in endothelial cells (ECs). In the BMP9/10-immunoblocked (BMP9/10ib) neonatal mouse model of HHT, we report here that the mTOR inhibitor, sirolimus, and the receptor tyrosine kinase inhibitor, nintedanib, could synergistically fully block, but also reversed, retinal AVMs to avert retinal bleeding and anemia. Sirolimus...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Signaling by the TGF-β superfamily is important in the regulation of hematopoiesis and is dysregulated in myelodysplastic syndromes (MDSs), contributing to ineffective hematopoiesis and clinical cytopenias. TGF-β, activins, and growth differentiation factors exert inhibitory effects on red cell formation by activating canonical SMAD2/3 pathway signaling. In this Review, we summarize evidence that overactivation of SMAD2/3 signaling pathways in MDSs causes anemia due to impaired erythroid maturation. We also describe the basis for biological activity of activin receptor ligand traps, novel fusion proteins such as ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
[Nation] Tax payers have lost Sh92 million after a new foot-and-mouth disease vaccine that had been manufactured by the veterinary agency expired following a tug-of-war between senior government officials and the corporation over a benchmarking trip.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Date: Tuesday, 01 28, 2020; Speaker: Ricardo T. Gazzinelli, Professor, University of Massachusetts Medical School; 12735 Twinbrook Pkwy; 2nd Floor Conference Room
Source: NIH Calendar of Events - Category: American Health Source Type: events
Publication date: Available online 20 January 2020Source: Materials Today: ProceedingsAuthor(s): Dina M. Hamoda, Sayed H. Kenawy, Gehan T. El-Bassyouni, Usama M. Rashed, Gamal M. TurkyAbstractTextile fabrics possess multitude applications and a wide variety of highly technical uses. Microfiber is one of the most popular synthetic fibers. Its popularity is a result of special properties such as good resiliency, heat resistance, light weight, water proof and durability. In the present work, two woven fabrics were synthesized from polyester microfiber and then coated by calcium silicate/copper oxide-nanoparticles, (CaO3Si/CuO...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
ConclusionsThese GCaMP6 transgenic lines thus provide useful tools for functional analysis of neuronal circuits in both central and peripheral nervous systems.
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Publication date: February 2020Source: The Annals of Thoracic Surgery, Volume 109, Issue 2Author(s): Hannes Müller, Thomas Ratschiller, Wolfgang Schimetta, Jens Meier, Hans Gombotz, Andreas ZiererBackgroundJehovah’s Witnesses (JW) refuse allogeneic blood transfusions and therefore pose a unique challenge in case of major surgery. This retrospective study reviewed an experience with JW patients who were undergoing open heart surgery.MethodsBy using patient blood management strategies, 35 adult JW patients underwent cardiac surgery at Kepler University Hospital in Linz, Austria between 2008 and 2017. Outcomes were...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
The objective of this work was to evaluate the physicochemical characteristics and technological functional properties of okara flours (OFs) obtained by different drying processes in forced air oven (FAD at 40, 50, 60, and 70 °C), microwave (MWD), and freeze drying (FRD). The OFs showed acidity range of 3–5.7 mEq NaOH/100 g, pH of 5.4–5.9, soluble solid of 0.6–1.3 ºBrix, luminosity of 78–85, and good technological functional properties (MWD-OF and FRD-OF showed ↑oil absorption capacity and ↑emulsifying capacity and FRD-OF showed foam capacity). The FAD70-OF, MWD-OF, and FRD-OF...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 007 When you think tropical medicine, malaria has to be near the top. It can be fairly complex and fortunately treatment has become a lot simpler. This post is designed to walk you through the basic principals with links to more in depth teaching if your niche is travel medicine, laboratory diagnostics or management of severe or cerebral malaria. If you stubbled on this post while drinking a cup of tea or sitting on the throne and want a fe...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine malaria Plasmodium plasmodium falciparum plasmodium knowles plasmodium malariae plasmodium ovale plasmodium vivax Source Type: blogs
More News: Anemia | Calcium | Children | G6PD | Genetics | Hematology | Hospitals | Kenya Health | Malaria | National Institutes of Health (NIH) | Parasitic Diseases | Parasitology | Research | Respiratory Medicine | Sickle Cell Anemia | Study