Epigenome wide association study of suicide attempt in schizophrenia

In this study, epigenome-wide patterns of methylation were measured in schizophrenia suicide attempters (n = 54) and in schizophrenia non suicide attempters (n = 69) using DNA extracted from white blood cells. Analyses focused on identifying differentially methylated CpG sites and gene regions between attempters and non-attempters. We identified the CpG site cg19647197 within the CCDC53 gene, which is characterized by hypomethylation of WBC in schizophrenia attempters compared to non-attempters. Our results suggest that there is variation in DNA methylation associated with suicide attempt that may offer novel highlights into the molecular mechanisms linked to suicide attempt associated with schizophrenia.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research