MST1 Suppression Reduces Early Brain Injury by Inhibiting the NF- κB/MMP-9 Pathway after Subarachnoid Hemorrhage in Mice.

Conclusions: The current findings indicate that MST1 participates in SAH-induced BBB disruption and white matter fiber damage via the downstream NF-κB-MMP-9 signaling pathway. Therefore, MST1 antagonists may serve as a novel therapeutic target to prevent early brain injury in SAH patients.
PMID: 30018671 [PubMed - in process]

Source: Behavioural Neurology - July 20, 2018 Category: Neurology Authors: Qu J, Zhao H, Li Q, Pan P, Ma K, Liu X, Feng H, Chen Y Tags: Behav Neurol Source Type: research