MST1 Suppression Reduces Early Brain Injury by Inhibiting the NF- κB/MMP-9 Pathway after Subarachnoid Hemorrhage in Mice.

Conclusions: The current findings indicate that MST1 participates in SAH-induced BBB disruption and white matter fiber damage via the downstream NF-κB-MMP-9 signaling pathway. Therefore, MST1 antagonists may serve as a novel therapeutic target to prevent early brain injury in SAH patients. PMID: 30018671 [PubMed - in process]
Source: Behavioural Neurology - Category: Neurology Authors: Tags: Behav Neurol Source Type: research

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Condition:   Stroke Intervention:   Device: Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) + Task Specifc Training Sponsors:   Medical University of South Carolina;   National Institutes of Health (NIH);   National Institute of General Medical Sciences (NIGMS) Not yet recruiting
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