Differences in Upper and Lower-body Adipose Tissue Oxygen Tension Contribute to the Adipose Tissue Phenotype in Humans.

Conclusions: We demonstrated for the first time that AT pO2 is higher in ABD than FEM subcutaneous AT in overweight/obese women, partly due to a lower oxygen consumption rate in ABD adipocytes. Moreover, low physiological pO2 decreased pro-inflammatory gene expression and improved the metabolic phenotype in differentiated human adipocytes, whereas more heterogeneous effects on adipokine secretion were found.
PMID: 30020463 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - July 17, 2018 Category: Endocrinology Authors: Vogel MAA, Jocken JWE, Sell H, Hoebers N, Essers Y, Rouschop KMA, Cajlakovic M, Blaak EE, Goossens GH Tags: J Clin Endocrinol Metab Source Type: research