Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-{beta} clearance in human astrocytes [Cell Biology]

In conclusion, FL APP is involved in the endocytosis of LDL receptor ligands and is required for proper cholesterol homeostasis and Aβ clearance in human astrocytes.

Source: Journal of Biological Chemistry - July 20, 2018 Category: Chemistry Authors: Lauren K. Fong, Max M. Yang, Rodrigo dos Santos Chaves, Sol M. Reyna, Vanessa F. Langness, Grace Woodruff, Elizabeth A. Roberts, Jessica E. Young, Lawrence S. B. Goldstein Tags: Molecular Bases of Disease Source Type: research