Repurposing metformin to prevent and treat tuberculosis

Respirology, EarlyView.
Source: Respirology - Category: Respiratory Medicine Authors: Source Type: research

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ConclusionsChest CT findings would therefore be useful for distinguishing PTB and MACLD when typical findings are observed.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
(University of Southampton) Researchers at the University of Southampton have identified how new checkpoint inhibitor treatments for cancer can activate tuberculosis in some patients.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Previously, we developed a 3-dimensional cell culture model of human tuberculosis (TB) and demonstrated its potential to interrogate the host-pathogen interaction (Tezera et al, 2017). Here, we use the model to investigate mechanisms whereby immune checkpoint therapy for cancer paradoxically activates TB infection. In patients, PD-1 is expressed inMycobacterium tuberculosis (Mtb)-infected lung tissue but absent in areas of immunopathology. In the microsphere model, PD-1 ligands are up-regulated by infection, and the PD-1/PD-L1 axis is further induced by hypoxia. Inhibition of PD-1 signalling increases Mtb growth, and augme...
Source: eLife - Category: Biomedical Science Tags: Immunology and Inflammation Source Type: research
This study will build an evidence base to inform future scale-up, implementation, and sustainability of ACF strategies in Cambodia and other similar settings. Implementation of this study will also complement TB control strategies in Cambodia by conducting ACF in operational districts without active interventions to find TB cases currently. Those who are ill and might have TB will be promptly screened, diagnosed, and linked to care. Early diagnosis and treatment initiation will also benefit their community by interrupting transmission and prevent further infections. The experience gained from this project will inform futur...
Source: Trials - Category: Research Source Type: clinical trials
Conclusion: HIV patients with the disseminated TB have higher risk for ocular TB. As ocular symptoms are rare, still all of them need a detailed ocular examination to look for active ocular TB which will reclassify isolated pulmonary/extrapulmonary to disseminated TB warranting a detailed systemic examination. PMID: 32083986 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Authors: De Smet D, Payen MC, Remes J, Van den Wijngaert S, Vouche M, Konopnicki D PMID: 32081503 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Publication date: Available online 27 January 2020Source: Current Medicine Research and PracticeAuthor(s): K.K. Chopra, Shweta SinghAbstractTuberculosis (TB) has remained a disease of public health importance since ages, affecting more than 10 million people globally and taking lives of 2 million people worldwide every year. Despite the dramatic improvements made in providing high-quality TB diagnostic services, since the discovery of the causative bacilli, many people with TB remain undiagnosed or get diagnosed only after long delays. Ten countries account for 77% of this gap and use only smear microscopy for diagnosis, w...
Source: Current Medicine Research and Practice - Category: General Medicine Source Type: research
Publication date: Available online 21 February 2020Source: Microbes and InfectionAuthor(s): Patrick Howlett, Elsa Du Bruyn, Hazel Morrison, Isiguzo C. Godsent, Katalin A. Wilkinson, Mpiko Ntsekhe, Robert J. WilkinsonAbstractTuberculous pericarditis is a severe form of extrapulmonary tuberculosis and is the commonest cause of pericardial effusion in high incidence settings. Mortality ranges between 8-34%, and it is the leading cause of pericardial constriction in Africa and Asia. Current understanding of the disease is based on models derived from studies performed in the 1940-50s. This review summarises recent advances in ...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
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