Multidimensional improvement in connective tissue disease ‐associated interstitial lung disease: Two courses of pulse dose methylprednisolone followed by low‐dose prednisone and tacrolimus

Respirology, EarlyView.
Source: Respirology - Category: Respiratory Medicine Authors: Source Type: research

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ConclusionsOur study suggests that the CAT can be applied to evaluate the lung ‐specific quality of life in SSc‐ILD similar to IIP regarding the pulmonary function, but it should be noted that pulmonary arterial hypertension in SSc‐ILD influences the CAT score.
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
Publication date: Available online 19 February 2020Source: Joint Bone SpineAuthor(s): Elisabetta Zanatta, Andrea Martini, Elena Scarpieri, Alessandra Biasiolo, Augusta Ortolan, Francesco Benvenuti, Franco Cozzi, Patrizia Pontisso, Andrea DoriaAbstractObjective: Interstitial lung disease (ILD) is the major determinant of prognosis in patients with systemic sclerosis (SSc). Squamous Cell Carcinoma Antigen (SCCA1) is a serin protease inhibitor which plays a pivotal role in inflammation and fibrosis. SCCA1 is overexpressed in pulmonary tissue of patients with idiopathic pulmonary fibrosis and can be detectable in serum as circ...
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
In this study, we analysed circulating and lung resident monocyte populations, and assessed their phenotype and recruitment from the blood to the lung in ILD. Flow cytometry analysis of blood samples for quantifying circulating monocytes was performed in 105 subjects: 83 with ILD (n=36, n=28 and n=19 for nonspecific interstitial pneumonia, hypersensitivity pneumonitis and connective-tissue disease-associated ILD, respectively), as well as 22 controls. Monocyte localisation and abundance were assessed using immunofluorescence and flow cytometry of lung tissue. Monocyte populations were cultured either alone or with endothel...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung biology and experimental studies, Interstitial and orphan lung disease Original Articles: Interstitial lung disease and basic science Source Type: research
In patients with fibrotic interstitial lung disease (ILD), hypoxaemia on exertion is frequent, and contributes to exercise intolerance, exertional dyspnoea and reduced quality of life [1–3]. Clinically significant exertional hypoxaemia is typically defined as a drop in transcutaneous arterial oxygen saturation (SpO2) to ≤88% on a 6-min walk test (6MWT) [4], and is associated with reduced survival in ILD patients [5].
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
In this study, we retrospectively analysed clinical, radiological and immunological data of a cohort of 42 patients affected by cHP: KL-6 concentrations were collected from serum and BAL. KL-6 clinical value was assessed through the analysis of association between KL-6 concentrations and clinical, functional, immunological and radiological features. KL-6 serum concentration results increased in 28/34 patients (82%). A positive direct correlation was observed between KL-6 concentrations in BAL and serum (r = 0.62,p 
Source: Internal and Emergency Medicine - Category: Emergency Medicine Source Type: research
To develop a screening tool for the detection of interstitial lung disease (ILD) patterns using a deep-learning method.
Source: Clinical Radiology - Category: Radiology Authors: Source Type: research
Publication date: Available online 15 February 2020Source: Best Practice &Research Clinical RheumatologyAuthor(s): Lucas L. van den Hoogen, Jacob M. van LaarAbstractTargeted therapies using biological disease-modifying antirheumatic drugs (bDMARDs) and small molecule synthetic drugs have revolutionized rheumatological practice. Initially developed for the treatment of immune arthritis (rheumatoid arthritis, psoriatic arthritis, and spondylarthritis), both bDMARDs and small molecule synthetic drugs are now increasingly entering the space of connective tissue disease (CTD) treatment. Recent clinical trial data in systemi...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
ConclusionsOur study suggests that the CAT can be applied to evaluate the lung ‐specific quality of life in SSc‐ILD similar to in IIP regarding the pulmonary function, but it should be noted pulmonary arterial hypertension in SSc‐ILD influences the CAT score.
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
International Journal of Rheumatic Diseases, Volume 23, Issue 2, Page 137-139, February 2020.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: EDITORIAL Source Type: research
Abstract Idiopathic inflammatory myopathies are autoimmune processes that are characterized by skeletal muscle inflammation. The lung is the most commonly involved extramuscular organ and, when present, pulmonary disease drives morbidity and mortality. A subset of patients can present with rapidly progressive hypoxemic respiratory failure due to myositis-related interstitial lung disease. Confirmatory autoantibody testing requires sending samples to a reference laboratory, thus diagnosis of rapidly progressive myositis-associated interstitial lung disease relies on a high index of suspicion and careful history and...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
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