Differential altered expression of let-7a and miR-205 tumor-suppressor miRNAs in different subtypes of breast cancer under treatment with Taxol.

CONCLUSIONS: Our results confirmed a better response of HER2-overexpressing breast cancer to paclitaxel at the miRNA level. One putative reason could be the upregulation of tumor-suppressor miRNAs after treatment with paclitaxel. On the other hand, HER2-negative breast cancer cell lines showed a significantly decreased expression of tumor-suppressor miRNAs, a putative mechanism of resisting the therapy.
PMID: 30019863 [PubMed - as supplied by publisher]

Source: Clinical Genitourinary Cancer - July 18, 2018 Category: Cancer & Oncology Authors: Asghari F, Haghnavaz N, Shanehbandi D, Khaze V, Baradaran B, Kazemi T Tags: Adv Clin Exp Med Source Type: research