Amyloid Precursor Protein Overexpression in Down Syndrome Trophoblast Reduces Cell Invasiveness and Interferes with Syncytialization

The placentas of Down syndrome (DS) pregnancies exhibit morphologic and functional abnormalities. Although the increase in dosage of certain genes on chromosome 21 has been associated with the DS phenotype, the effects on placenta have seldom been studied. Here we examine the expression of four dosage sensitive genes APP, ETS2, SOD1, and HMGN1 in normal and DS placentas. We demonstrated significant overexpression of amyloid precursor protein (APP) in DS placentas at RNA and protein levels by qPCR, western blot, and immunohistochemistry.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular article Source Type: research