Unexpected High Incidence of Human Herpesvirus-6 Encephalitis After Naive T Cell-Depleted Graft of Haploidentical Stem Cell Transplantation in Pediatric Patients

Graft versus host disease (GvHD) remains a major cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT).[1] The incidence of GvHD varies between 30% –70% in terms of donor recipient human leukocyte antigen (HLA) compatibility.[2–5] Donor T cells in the transplanted graft contribute to the development of GvHD[1,3]; thus, T cell-depleted grafts (TCD) constitute a strategy to overcome GvHD in HSCT.[6] Mobilized peripheral blood from a haploiden tical relative constitutes an alternative source when a matched HLA donor is not available.

Source: Biology of Blood and Marrow Transplantation - July 19, 2018 Category: Hematology Authors: Sisinni L, M Gasior, R de Paz, S Querol, D Bueno, L Fern ández, J Marsal, A Sastre, R Gimeno, L Alonso, I Badell, E López-Granados, J Torres, L Medina, M Torrent, C Diaz de Heredia, A Escudero, A Pérez-Martínez Source Type: research