Association Between Magnetic Resonance Imaging-Proton Density Fat Fraction and Liver Histology Features in Patients With Nonalcoholic Fatty Liver Disease or Nonalcoholic Steatohepatitis

Patients with nonalcoholic fatty liver disease (NAFLD) or nonalcoholic; steatohepatitis (NASH) often require histologic assessment via liver biopsy. Magnetic; resonance imaging (MRI)-based methods for measuring liver triglycerides based on proton density fat fraction (PDFF) are increasingly as a non-invasive tool to identify patients with hepatic steatosis and to assess for change in liver fat over time. We aimed to determine whether MRI-PDFF accurately reflects a variety of liver histology features in patients with NAFLD or NASH.

Source: Gastroenterology - July 19, 2018 Category: Gastroenterology Authors: Benjamin Wildman-Tobriner, Michael M. Middleton, Cynthia A. Moylan, Stephen Rossi, Omar Flores, Zac Anchi Chang, Manal F. Abdelmalek, Claude B. Sirlin, Mustafa R. Bashir Source Type: research