QTc interval in takotsubo cardiomyopathy: How the activation of insular cortex interacts

Clinical Cardiology, EarlyView.
Source: Clinical Cardiology - Category: Cardiology Authors: Source Type: research

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Publication date: Available online 19 February 2020Source: Arab Journal of GastroenterologyAuthor(s): Mehmet Baysal, Yıldız Ortaburun, Ali Rıza Soylu, Mustafa Adem Yılmaztepe, Serap Baysal, Elif Umit, Hasan Umit, Ahmet Tezel, Ahmet Muzaffer DemirAbstractBackground and study aimsCirrhosis is a multisystem disorder characterized by hyperdynamic circulation which can progress to multiple organ dysfunctions. Recent studies have demonstrated autonomic dysfunction and cirrhotic cardiomyopathy including diastolic dysfunction, systolic dysfunction with electrophysiologic abnormalities in patients with cirrhosis. Due to the lon...
Source: Arab Journal of Gastroenterology - Category: Gastroenterology Source Type: research
AbstractBackgroundImplantable cardioverter-defibrillators (ICDs) are designed to deliver therapy in the event of malignant ventricular arrhythmias. Despite their benefits, some ICD recipients regret their decision on device implantation.ObjectivesThe aim of this study was to evaluate the incidence, predictors, and consequences of recipients that regretted their decision after implantation.MethodsA questionnaire-based cross-sectional survey of consecutive ICD recipients examined during a  routine outpatient follow-up visit was conducted. Their level of depression and anxiety was assessed with the hospital anxiety and d...
Source: Herzschrittmachertherapie und Elektrophysiologie - Category: Cardiology Source Type: research
An 18 y.o. female who presented for chest pain. Patient reports productive cough and headache x 4 days. She notes persistent sternal chest pain worse at night and waking her from sleep. She also notes intermittent abdominal pain, describing as a " tightness " ." Sinus arrhythmia with variable right bundle origin PVCs "Is this accurate?No.This is sinus bradycardia with a slightly accelerated right ventricular escape, such that sometimes:1.  the sinus beat is conducted before any ventricular escape (beats 7)2.  the ventricular beat starts at almost the exact same time as the P-wave, and the P-wa...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
This study aimed to determine the time course of development of diabetic cardiomyopathy in a model of type 1 diabetes (T1D) in vivo. Diabetes was induced in 6-week-old male FVB/N mice via streptozotocin (55 mg/kg i.p. for 5 days; controls received citrate vehicle). At 2, 4, 8, 12, and 16 weeks of untreated diabetes, left ventricular (LV) function was assessed by echocardiography before post-mortem quantification of markers of LV cardiomyocyte hypertrophy, collagen deposition, DNA fragmentation, and changes in components of the hexosamine biosynthesis pathway (HBP) were assessed. Blood glucose and HbA1c levels were elevated...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Nature Reviews Cardiology, Published online: 20 February 2020; doi:10.1038/s41569-020-0339-2Diabetic cardiomyopathy occurs as a result of the dysregulated glucose and lipid metabolism, increased oxidative stress and activation of pro-inflammatory pathways associated with diabetes mellitus, which can induce cardiac remodelling and dysfunction. In this Review, Tan and colleagues discuss the pathogenesis of diabetic cardiomyopathy and describe signalling pathways that might be potential therapeutic targets.
Source: Nature Reviews Cardiology - Category: Cardiology Authors: Source Type: research
The objective of the present work was to study from a metabolic point of view the side effects of DOX and the protective properties of DEX. In vitro1H-NMR metabonomics was applied to the rat cardiomyoblastic H9C2 cell line. This strategy was used with the hope of unveiling possible new targets to cope with DOX cardiotoxicity. Another underlying goal was the validation of H9C2 in vitro model for metabolic investigations of DOX and DEX effects. For this purpose, several parameters, including oxidative stress, cell mortality, and apoptosis, were measured to assess the effects of DOX and DEX alone or in combination. The metabo...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In the current issue of the International Journal of Cardiology, the article by Rizvi et al. adds significant evidence to the current body of knowledge regarding the pathophysiological mechanisms involved in post cardiac surgery new onset atrial fibrillation (PoAF) [1]. The incidence [2], predictive factors [3] and prognostic value of this PoAF have been thoroughly studied, but no randomized study has managed to obtain a decrease in incidence or an improvement in prognosis. Moreover, it is still unclear whether PoAF should be treated as an epiphenomenon linked to the acute setting and cardiac injury, or as the first sympto...
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
Hypertrophic cardiomyopathy is a heterogeneous disease in which an implantable cardioverter defibrillator (ICD) effectively prevents sudden cardiac death in at-risk individuals. Nevertheless, the cost-effectiveness of ICDs in this specific patient group has not been evaluated.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Condition:   Hypertrophic Obstructive Cardiomyopathy Intervention:   Sponsor:   Xijing Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: Our study showed that NLVS defines a group of systolic HF patients which not only did not have less severe disease than those with enlarged left ventricules (i.e., DCM), also had more HF rehospitalization. These NLVS patients also had steady clinical, laboratory, and echocardiographic profile during follow-up.
Source: Critical Pathways in Cardiology - Category: Cardiology Tags: Original Articles Source Type: research
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